Scientific Publications

An increasing number of peer-reviewed publications reference M2-Automation’s microdispensing instruments. These studies cover a variety of research areas, including the life sciences, diagnostics, protein microarrays, nanoliter dispensing, biosensors, and biomarker discovery. The following list provides an overview of how M2 technologies have contributed to scientific applications in various fields.

Featured Scientific Publications

Sascha D. Braun et al.
High-throughput screening of monoclonal antibodies against carbapenemases using a multiplex protein microarray platform.
Frontiers in Microbiology (2025)
Institutions: Leibniz Institute of Photonic Technology (Leibniz-IPHT), InfectoGnostics Research Campus Jena, INTER-ARRAY / fzmb GmbH, Institut Virion\Serion GmbH, Friedrich Schiller University Jena
M2 technology: Fully automated M2 spotter
Read full article

 

Mete Aslan, Elif Seymour, Howard Brickner, Alex E. Clark, Iris Celebi, Michael B. Townsend, Panayampalli S. Satheshkumar, Megan Riley, Aaron F. Carlin, M. Selim Ünlü, Partha Ray
A label-free optical biosensor-based point-of-care test for the rapid detection of Monkeypox virus.
Biosensors and Bioelectronics, Volume 269, 116932 (2025)
Institutions: Boston University, iRiS Kinetics, University of California San Diego, Centers for Disease Control and Prevention (CDC), axiVEND
M2 technology: iONE-600
Read full article

 

Kayan Awawdeh, Xin Jiang, Lisa Dahan, Matan Atias, Janina Bahnemann, Ester Segal
Porous silicon biosensors meet zwitterionic peptides: tackling biofouling from proteins to cells.
Nanoscale Horizons, 10, 3072–3084 (2025)
Institutions: Technion – Israel Institute of Technology, University of Augsburg, Centre for Advanced Analytics and Predictive Sciences (CAAPS)
M2 technology: iTWO-300P with PDMD microdispenser
Read full article

 

Braun, S.D.; Müller, E.; Frankenfeld, K.; Gary, D.; Monecke, S.; Ehricht, R.
A Proof-of-Concept Protein Microarray-Based Approach for Serotyping of Salmonella enterica Strains.
Pathogens 2024, 13, 355
Institutions: Leibniz Institute of Photonic Technology (Leibniz-IPHT), InfectoGnostics Research Campus Jena, INTER-ARRAY / fzmb GmbH, Friedrich Schiller University Jena
M2 technology: Fully automated M2 spotter
Read full article

 

García-Arroyo, R.; Domènech, E.B.; Herrera-Úbeda, C.; Asensi, M.A.; Núñez de Arenas, C.; Cuezva, J.M.; Garcia-Fernàndez, J.; Pallardó, F.V.; Mirra, S.; Marfany, G.
Exacerbated response to oxidative stress in the Retinitis Pigmentosa CerklKD/KO mouse model triggers retinal degeneration pathways upon acute light stress.
Redox Biology, Volume 66, 102862 (2023)
Institutions: Universitat de Barcelona, IBUB-IRSJD, CIBERER, University of Valencia-INCLIVA, Centro de Biología Molecular Severo Ochoa (CSIC-UAM), Instituto de Investigación Hospital 12 de Octubre
M2 technology: iTWO-300P with Piezo Driven Micro-Dispenser (PDMD)
Read full article

 

Krämer, S., Moritz, A., Stehl, L. et al.
An ultra-high-throughput screen for the evaluation of peptide HLA-Binder interactions.
Scientific Reports 13, 5290 (2023)
Institutions: BioCopy GmbH, BioCopy AG, Immatics Biotechnologies GmbH
Read full article

 

Zhijun Lin, Mengyao Liu, Wei Xing, Fenghua Wang, Hongxia Zhang, Xiaoli Wei, Hans Schmitthenner, Xi Xie, Xiaojun Xia, Jiang Yang
A near-infrared fluorescence-enhancing plasmonic biosensing microarray identifies soluble PD-L1 and ICAM-1 as predictive checkpoint biomarkers for cancer immunotherapy.
Biosensors and Bioelectronics, Volume 240, 115633 (2023)
M2 technology: Piezo Driven Micro-Dispenser (PDMD)
Read full article

 

Multiplexed COVID-19 antibody quantification from human sera using label-free nanoplasmonic biosensors.
Biomedical Optics Express (2022)
Institutions: University of Wisconsin-Madison and collaborating clinical research groups
M2 technology: iTWO-300; 150 pL protein droplets
Read full article

 

Monika Conrad, Günther Proll, Esteban Builes-Münden, Andreas Dietzel, Sven Wagner, Günter Gauglitz
Tools to compare antibody gold nanoparticle conjugates for a small molecule immunoassay.
Microchimica Acta (2023)
Institutions: University of Tübingen and collaborating German research institutions
M2 technology: instrumentTWO / non-contact dispensing
Read full article

 

Nanoribbon Biosensor-Based Detection of microRNA Markers of Prostate Cancer.
Sensors (2023)
Institutions: Institute of Biomedical Chemistry (IBMC) and collaborating biomedical research institutes
M2 technology: iONE-600
Read full article

 

Aidana Beisenova, Wihan Adi, S. Janna Bashar, Monniiesh Velmurugan, Kenzie B. Germanson, Miriam A. Shelef, Filiz Yesilkoy
Rapid COVID-19 immunity screening by machine learning aided multiplexed nanoplasmonic biosensor.
Proc. SPIE 12648, Plasmonics: Design, Materials, Fabrication, Characterization, and Applications XXI, 1264808 (2023)
Read full article

 

Matyushkina, D.; Shokina, V.; Tikhonova, P.; Manuvera, V.; Shirokov, D.; Kharlampieva, D.; Lazarev, V.; Varizhuk, A.; Vedekhina, T.; Pavlenko, A.; et al.
Autoimmune Effect of Antibodies against the SARS-CoV-2 Nucleoprotein.
Viruses 2022, 14, 1141
M2 technology: iTWO-300P
Read full article

 

Microarray Profiling of Vaccination-Induced Antibody Responses to SARS-CoV-2 Variants of Interest and Concern.
International Journal of Molecular Sciences 2022, 23, 13220
M2 technology: iTWO-300P
Read full article

 

Ivanov, Y.D.; Malsagova, K.A.; Goldaeva, K.V.; Pleshakova, T.O.; Shumov, I.D.; Galiullin, R.A.; Kapustina, S.I.; Iourov, I.Y.; Vorsanova, S.G.; Ryabtsev, S.V.; et al.
"Silicon-On-Insulator"-Based Nanosensor for the Revelation of MicroRNA Markers of Autism.
Genes 2022, 13, 199
M2 technology: iONE with PDMD
Read full article

 

Stolpovsky, Y.A., Kuznetsov, S.B., Solodneva, E.V. et al.
New Cattle Genotyping System Based on DNA Microarray Technology.
Russian Journal of Genetics 58, 885–898 (2022)
Read full article

 

Effective therapeutic strategies in a preclinical mouse model of Charcot–Marie–Tooth disease.
Human Molecular Genetics (2021)
Institutions: Universidad Autónoma de Madrid, Centro de Biología Molecular Severo Ochoa (CSIC-UAM), CIBERER, Instituto de Investigación Hospital 12 de Octubre and collaborators
M2 technology: iTWO-300P with PDMD
Read full article

 

Aptamer-Sensitized Nanoribbon Biosensor for Ovarian Cancer Marker Detection in Plasma.
Chemosensors 2021, 9, 222
Institution: Institute of Biomedical Chemistry (IBMC) and collaborating research institutes
M2 technology: iONE-600 with PDMD
Read full article

 

Valery Konopsky, Tatiana Mitko, Konstantin Aldarov, Elena Alieva, Dmitry Basmanov, Aleksandr Moskalets, Ainur Matveeva, Olga Morozova, Dmitry Klinov
Photonic crystal surface mode imaging for multiplexed and high-throughput label-free biosensing.
Biosensors and Bioelectronics, Volume 168, 112575 (2020)
Read full article

 

Yvanoff, C., Torino, S., Willaert, R.G.
Robotic Cell Printing for Constructing Living Yeast Cell Microarrays in Microfluidic Chips.
Fermentation 2020, 6, 26
M2 technology: iTWO-400 with PDMD
Read full article

 

Henkel, S., Wellhausen, R., Woitalla, D., Marcus, K., May, C.
Epitope Mapping Using Peptide Microarray in Autoantibody Profiling.
In: Li, P., Sedighi, A., Wang, L. (eds) Microarray Technology. Methods in Molecular Biology, vol 1368. Humana Press, New York, NY (2016)
Read full article

 

Sarah Schumacher, Harald Seitz
A novel immunoassay for quantitative drug abuse screening in serum.
Journal of Immunological Methods, Volume 436, 2016, Pages 34–40
Read full article

 

Sarah Schumacher, Harald Seitz
Quality control of antibodies for assay development.
New Biotechnology, Volume 33, Issue 5, Part A, 2016, Pages 544–550
Read full article

 

Mikko Hölttä, Lennart Minthon, Oskar Hansson, Jessica Holmén-Larsson, Ian Pike, Malcolm Ward, Karsten Kuhn, Ulla Rüetschi, Henrik Zetterberg, Kaj Blennow, Johan Gobom
An Integrated Workflow for Multiplex CSF Proteomics and Peptidomics—Identification of Candidate Cerebrospinal Fluid Biomarkers of Alzheimer’s Disease.
Journal of Proteome Research 2015, 14 (2), 654–663
Read full article

 

María Díaz-González, J. Pablo Salvador, Diana Bonilla, M. Pilar Marco, César Fernández-Sánchez, Antoni Baldi
A microfluidic device for the automated electrical readout of low-density glass-slide microarrays.
Biosensors and Bioelectronics, Volume 74, 2015, Pages 698–704
Read full article

 

May C, Nordhoff E, Casjens S, Turewicz M, Eisenacher M, Gold R, et al.
Highly Immunoreactive IgG Antibodies Directed against a Set of Twenty Human Proteins in the Sera of Patients with Amyotrophic Lateral Sclerosis Identified by Protein Array.
PLoS ONE 9(2): e89596 (2014)
Read full article